Enrichment with tDMRs in the gene- and CpG-density centric annotation. Differences were observed between CGI and non-CGI regions, especially in proximal promoters and downstream regions. Shores in distal promoters and downstream regions were enriched with tDMR CpGs. Enrichment with tDMR CpGs in non-CGI features was limited to distal promoters and proximal promoters. * P < 10-5. CGI, CpG island; tDMR, tissue-specific differentially methylated region.