Figure 5

Cross-correlation between the genomic and proteomic data. (A) Example of cross-correlation analysis between the gene expression of a given enzyme (in this example, EZH2.2 variant) to the histone PTM log₂ abundance (in this example, H3K9me3K14un) across all 24 lines (diamond). (B) Hierarchical clustering of Pearson correlation coefficients for each enzyme and histone H3 PTM cross-correlation analysis. For instance, a positive correlation would indicate that increased enzyme transcript level is associated with increased PTM level. (C) Comparison between enrichment of histone H3 PTMs for MCF7 and MdaMB231 (same data as found in Figure 3) and the correlation between those same H3 PTMs with EZH2 (EZH2.1 and EZH2.2) and MYST1 expression. Note, for instance, the enrichment of a given PTM (for instance, K27me3K36me2) in the two lines is generally accompanied by a positive correlation of EZH2, and a negative correlation of MYST1, for that PTM.