RNA Pol II occupancy at the centromeric promoter and dg repeat in med18+and med20+deletion strains. ChIP analyses show that compared to wild-type, the RNA Pol II occupancy at (A) the dg centromeric promoter as well as at (B) the dg repeat is increased in med18+ and med20+ deletion strains. For comparison, the RNA Pol II occupancy in a clr4Δ deletion strain is also shown. *P <0.004; **P <1e to −6. The strains for this figure were: WT (FY498), med18Δ (MT42), and med20Δ (MT26), and clr4Δ (PG3423).