Figure 4
From: Deacetylation of H4-K16Ac and heterochromatin assembly in senescence
Relative abundance of H4 acetylation states measured on the Gly 4 -Arg 17 peptide by mass spectrometry (MS) analyses. Error bars show SD of at least three biological replicates. Prolif.: proliferating WI-38hTERT/GFP-RAF-ER; SenRAF: WI-38hTERT/GFP-RAF-ER + 20 nM 4-HT (5 days); Quiescent: serum-starved WI-38hTERT/GFP-RAF-ER (5 days); SenETO: WI-38hTERT/GFP-RAF-ER + 20 μM etoposide (5 days); Control 4-HT: WI-38hTERT + 20 nM 4-HT (5 days); PD 43: population doubling 43, proliferating WI-38 cells; PD 65: replicatively senescent WI-38 population.