Figure 5
From: MK3 controls Polycomb target gene expression via negative feedback on ERK
Model for MAPK/MK regulation of PRC1 target genes. The PRC1/MK/ERK module represents a molecular switch mechanism: fine-tuning of converging P38 and ERK signals at the chromatin level triggers a potential methylphosphoryl switching module and a signaling-dependent disruption of the PRC1/chromatin association that permits gene activation. Transient H3S28ph, but not removal of H3K27me3, accompanies gene expression. Concomitant MK activation initiates DUSP-dependent negative regulatory feedback on MEK/ERK (and possibly also on H3S28ph; dashed lines reflect potential functional relationships).