Phenotypes observed in gene disruption studies of HATs. Phenotypes associated with HAT genetic knockout (KO) or RNAi targeting in mouse development and embryonic stem cell (ESC) pluripotency, respectively. For mouse KO, the day of embryonic death (ED) for homozygous animals is presented as a phenotype readout parameter. For the effect on mouse embryonic stem cell (mESC) pluripotency, any observation (e.g., flattening of the cells, differentiation) was simplified as a positive phenotype (+). ND represents HATs for which the parameter was not determined. References [19–22, 35, 36] cited in figure.