Epigenetics & Chromatin

Table 1 Analyses of pairs of unrelated individuals

From: Extensive sequence-influenced DNA methylation polymorphism in the human genome

								Observed		MO/OO	Expected
Ind. 1	Ind. 2	Cell Type	I - SNPs	Ind. 1 A-	Ind. 1 B-	Ind. 2 A-	Ind. 2 B-		P
								MO	OO		MO	OO		MO: (O–E)/I, %
GM12096	GM10849	LBL	7525	440	379	421	417	207	38	5.4	45.6	46.5	3.6 × 10^-27	2.14
GM12097	GM10849	LBL	5469	663	590	315	261	172	30	5.7	66.3	65.6	1.7 × 10^-23	1.93
GM12099	GM10848	LBL	9266	761	630	839	649	418	45	9.3	113.0	110.3	2.6 × 10^-67	3.29
GM10848	GM10849	LBL	8346	630	493	545	496	295	52	5.7	70.4	69.6	6.8 × 10^-39	2.69
GM10848	GM12698	LBL	8189	665	533	387	320	217	40	5.4	52.3	51.2	2.4 × 10^-28	2.01
GM10848	GM12699	LBL	7678	575	491	710	578	323	46	7.0	90.1	88.7	3.9 × 10^-47	3.03
GM10848	GM12706	LBL	9944	802	674	1234	1179	461	124	3.7	179.4	178.7	4.0 × 10^-44	2.83
GM10849	GM12698	LBL	7340	483	414	315	248	147	32	4.6	34.7	34.1	8.3 × 10^-18	1.53
GM10849	GM12699	LBL	7141	461	392	641	548	290	39	7.4	71.5	70.6	1.5 × 10^-43	3.06
GM10849	GM12706	LBL	9118	636	537	1044	1071	356	112	3.2	135.9	136.2	1.7 × 10^-29	2.41
GM12698	GM12699	LBL	7013	310	269	644	536	167	43	3.9	49.0	48.4	1.2 × 10^-17	1.68
GM12089	GM12706	LBL	9627	1136	859	1142	1116	439	173	2.5	234.3	233.6	5.8 × 10^-27	2.13
PWBC1	PWBC3	WBC	6713	155	203	102	147	69	15	4.6	6.8	6.5	3.8 × 10^-09	0.93
PWBC2	PWBC3	WBC	7405	101	138	124	174	67	16	4.2	4.9	4.7	2.2 × 10^-08	0.84
Averages										5.2				2.18

I = informative; Ind. = individual; MO = methylation overlap; O-E = observed minus expected; OO = opposite overlap; SNP = single nucleotide polymorphism.
For the comparison of MO versus OO, the χ² P values were calculated.

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ISSN: 1756-8935

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