Epigenetics & Chromatin is affiliated with the International Society for Molecular and Clinical Epigenetics (isMOCLEP). isMOCLEP is open to all those interested in the wide spectrum of epigenetic research, from molecular to clinical aspects. isMOCLEP community welcomes academic researchers, early career scientists, companies, policy makers, and beyond.
Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature
Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methy...