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  1. Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt–Ada–Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and ...

    Authors: Varinia García-Molinero, José García-Martínez, Rohit Reja, Pedro Furió-Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez-Ortín and Susana Rodríguez-Navarro
    Citation: Epigenetics & Chromatin 2018 11:13
    Content type: Research Published on:

  2. DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorph...

    Authors: Karla M. O’Neill, Rachelle E. Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E. P. Loughery, Darragh G. McArt and Colum P. Walsh
    Citation: Epigenetics & Chromatin 2018 11:12
    Content type: Research Published on:

  3. Controlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core—including...

    Authors: Andrew T. Fenley, Ramu Anandakrishnan, Yared H. Kidane and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:11
    Content type: Research Published on:

  4. The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, t...

    Authors: Alejandro Saettone, Jyoti Garg, Jean-Philippe Lambert, Syed Nabeel-Shah, Marcelo Ponce, Alyson Burtch, Cristina Thuppu Mudalige, Anne-Claude Gingras, Ronald E. Pearlman and Jeffrey Fillingham
    Citation: Epigenetics & Chromatin 2018 11:10
    Content type: Research Published on:

  5. It has been reported that USP7 (ubiquitin-specific protease 7) prevents ubiquitylation and degradation of DNA methyltransferase 1 (DNMT1) by direct binding of USP7 to the glycine-lysine (GK) repeats that join ...

    Authors: Olya Yarychkivska, Omid Tavana, Wei Gu and Timothy H. Bestor
    Citation: Epigenetics & Chromatin 2018 11:9
    Content type: Research Published on:

  6. Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inheritance of disease (e.g., obesity) through the germline. The current study was designed to investigate the DDT...

    Authors: Michael K. Skinner, Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Margaux McBirney, Rachel Klukovich, Yeming Xie, Chong Tang and Wei Yan
    Citation: Epigenetics & Chromatin 2018 11:8
    Content type: Research Published on:

  7. The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control ...

    Authors: Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli and Didier Trono
    Citation: Epigenetics & Chromatin 2018 11:7
    Content type: Research Published on:

  8. DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine meth...

    Authors: Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker and Remo Rohs
    Citation: Epigenetics & Chromatin 2018 11:6
    Content type: Research Published on:

  9. The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER bin...

    Authors: Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck and Joseph Torchia
    Citation: Epigenetics & Chromatin 2018 11:5
    Content type: Research Published on:

  10. Protein posttranslational modifications (PTMs) occur broadly in the human proteome, and their biological outcome is often mediated indirectly by reader proteins that specifically bind to modified proteins and ...

    Authors: Agnieszka Anna Rawłuszko-Wieczorek, Franziska Knodel, Raluca Tamas, Arunkumar Dhayalan and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2018 11:4
    Content type: Methodology Published on:

  11. It is well recognized that the interphase chromatin of higher eukaryotes folds into non-random configurations forming territories within the nucleus. Chromosome territories have biologically significant proper...

    Authors: Nicholas Allen Kinney, Igor V. Sharakhov and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:3
    Content type: Research Published on:

  12. Histones organize DNA into chromatin through a variety of processes. Among them, a vast diversity of histone variants can be incorporated into chromatin and finely modulate its organization and functionality. ...

    Authors: Sara El Kennani, Annie Adrait, Olga Permiakova, Anne-Marie Hesse, Côme Ialy-Radio, Myriam Ferro, Virginie Brun, Julie Cocquet, Jérôme Govin and Delphine Pflieger
    Citation: Epigenetics & Chromatin 2018 11:2
    Content type: Methodology Published on:

  13. The timing of the first cell divisions may predict the developmental potential of an embryo, including its ability to establish pregnancy. Besides differences related to metabolism, stress, and survival, embr...

    Authors: Jessica Ispada, Camila Bruna de Lima, Marc-André Sirard, Patrícia Kubo Fontes, Marcelo Fábio Gouveia Nogueira, Kelly Annes and Marcella Pecora Milazzotto
    Citation: Epigenetics & Chromatin 2018 11:1
    Content type: Research Published on:

  14. The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones modifications, determine epigenetics properties of chroma...

    Authors: Viacheslav M. Morozov, Serena Giovinazzi and Alexander M. Ishov
    Citation: Epigenetics & Chromatin 2017 10:63
    Content type: Research Published on:

  15. SWI/SNF is a large heterogeneous multi-subunit chromatin remodeling complex. It consists of multiple sets of mutually exclusive components. Understanding how loss of one sibling of a mutually exclusive pair af...

    Authors: Jesse R. Raab, John S. Runge, Camarie C. Spear and Terry Magnuson
    Citation: Epigenetics & Chromatin 2017 10:62
    Content type: Research Published on:

  17. DNA methylation is a fundamental epigenetic modification that is involved in many biological systems such as differentiation and disease. We and others recently showed that some transcription factors (TFs) are...

    Authors: Takahiro Suzuki, Shiori Maeda, Erina Furuhata, Yuri Shimizu, Hajime Nishimura, Mami Kishima and Harukazu Suzuki
    Citation: Epigenetics & Chromatin 2017 10:60
    Content type: Methodology Published on:

  18. The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methylt...

    Authors: Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués and Francesc Piferrer
    Citation: Epigenetics & Chromatin 2017 10:59
    Content type: Research Published on:

  19. TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been inve...

    Authors: Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A. Medina, Antonio Jordán-Pla, José E. Pérez-Ortín, Xenia Peñate and Sebastián Chávez
    Citation: Epigenetics & Chromatin 2017 10:58
    Content type: Methodology Published on:

  21. In eukaryotes, heterochromatin replicates late in S phase of the cell cycle and contains specific covalent modifications of histones. SuUR mutation found in Drosophila makes heterochromatin replicate earlier than...

    Authors: Olga V. Posukh, Daniil A. Maksimov, Petr P. Laktionov, Dmitry E. Koryakov and Stepan N. Belyakin
    Citation: Epigenetics & Chromatin 2017 10:56
    Content type: Research Published on:

  23. Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers. It is a multifunctiona...

    Authors: Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu and James R. Davie
    Citation: Epigenetics & Chromatin 2017 10:54
    Content type: Research Published on:

  25. After the publication of this work [1], it was noticed that an initial was missing from the author name: Jeffrey Hayes. His name should be written as: Jeffrey J. Hayes.

    Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes and Elena Rustchenko
    Citation: Epigenetics & Chromatin 2017 10:52
    Content type: Correction Published on:

    The original article was published in Epigenetics & Chromatin 2017 10:49

  26. We have previously reported a novel O-GlcNAc modification at serine 40 (S40) of H2A (H2AS40Gc). S40-type H2A isoforms susceptible to O-GlcNAcylation are evolutionarily new and restricted to the viviparous animals...

    Authors: Koji Hayakawa, Mitsuko Hirosawa, Ruiko Tani, Chikako Yoneda, Satoshi Tanaka and Kunio Shiota
    Citation: Epigenetics & Chromatin 2017 10:51
    Content type: Research Published on:

  27. Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of w...

    Authors: Elena Denisenko, Reto Guler, Musa M. Mhlanga, Harukazu Suzuki, Frank Brombacher and Sebastian Schmeier
    Citation: Epigenetics & Chromatin 2017 10:50
    Content type: Research Published on:

  28. The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have...

    Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes and Elena Rustchenko
    Citation: Epigenetics & Chromatin 2017 10:49
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2017 10:52

  29. The distinct functional effects of the replication-dependent histone H2A isoforms have been demonstrated; however, the mechanistic basis of the non-redundancy remains unclear. Here, we have investigated the sp...

    Authors: Saikat Bhattacharya, Divya Reddy, Vinod Jani, Nikhil Gadewal, Sanket Shah, Raja Reddy, Kakoli Bose, Uddhavesh Sonavane, Rajendra Joshi and Sanjay Gupta
    Citation: Epigenetics & Chromatin 2017 10:48
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:67

  30. Epigenetics allows for the inheritance of information in cellular lineages during differentiation, independent of changes to the underlying genetic sequence. This raises the question of whether epigenetic mech...

    Authors: Michael A. Christopher, Stephanie M. Kyle and David J. Katz
    Citation: Epigenetics & Chromatin 2017 10:47
    Content type: Review Published on:

  31. It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic response...

    Authors: Vincenzo Cavalieri and Giovanni Spinelli
    Citation: Epigenetics & Chromatin 2017 10:46
    Content type: Review Published on:

  32. Histone post-translational modifications (PTMs) play central roles in chromatin-templated processes. Combinations of two or more histone PTMs form unique interfaces for readout and recruitment of chromatin int...

    Authors: Rebekka Mauser, Goran Kungulovski, Corinna Keup, Richard Reinhardt and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2017 10:45
    Content type: Methodology Published on:

  33. Gene promoters in vertebrate genomes show distinct chromatin features such as stably positioned nucleosome array and DNA hypomethylation. The nucleosomes are known to have certain sequence preferences, and the...

    Authors: Ryohei Nakamura, Ayako Uno, Masahiko Kumagai, Shinichi Morishita and Hiroyuki Takeda
    Citation: Epigenetics & Chromatin 2017 10:44
    Content type: Research Published on:

  34. Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activa...

    Authors: Taosui Li, Jacob W. Hodgson, Svetlana Petruk, Alexander Mazo and Hugh W. Brock
    Citation: Epigenetics & Chromatin 2017 10:43
    Content type: Research Published on:

  35. DNA methylation plays important roles in many regulatory processes in plants. It is economically infeasible to profile genome-wide DNA methylation at a single-base resolution in maize, given its genome size o...

    Authors: Fei-Man Hsu, Ming-Ren Yen, Chi-Ting Wang, Chien-Yu Lin, Chung-Ju Rachel Wang and Pao-Yang Chen
    Citation: Epigenetics & Chromatin 2017 10:42
    Content type: Methodology Published on:

  37. The dynamics of histone modifications in Plasmodium falciparum indicates the existence of unique mechanisms that link epigenetic factors with transcription. Here, we studied the impact of acetylated histone code ...

    Authors: Archana P. Gupta, Lei Zhu, Jaishree Tripathi, Michal Kucharski, Alok Patra and Zbynek Bozdech
    Citation: Epigenetics & Chromatin 2017 10:40
    Content type: Research Published on:

  38. The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an ‘open’ local chromatin configuration has long been known. However, the 3D topography of TREs wi...

    Authors: Marion Cremer, Volker J. Schmid, Felix Kraus, Yolanda Markaki, Ines Hellmann, Andreas Maiser, Heinrich Leonhardt, Sam John, John Stamatoyannopoulos and Thomas Cremer
    Citation: Epigenetics & Chromatin 2017 10:39
    Content type: Research Published on:

  39. Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by deve...

    Authors: Alexander M. Vaiserman, Alexander K. Koliada and Randy L. Jirtle
    Citation: Epigenetics & Chromatin 2017 10:38
    Content type: Review Published on:

  40. There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail...

    Authors: Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M. Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann and Bernhard Horsthemke
    Citation: Epigenetics & Chromatin 2017 10:37
    Content type: Research Published on:

  41. Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that v...

    Authors: Kevin T. Ebata, Kathryn Mesh, Shichong Liu, Misha Bilenky, Alexander Fekete, Michael G. Acker, Martin Hirst, Benjamin A. Garcia and Miguel Ramalho-Santos
    Citation: Epigenetics & Chromatin 2017 10:36
    Content type: Research Published on:

  42. In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-gl...

    Authors: Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov and Sergey V. Razin
    Citation: Epigenetics & Chromatin 2017 10:35
    Content type: Research Published on:

  43. Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttransla...

    Authors: Simone Sidoli, Congcong Lu, Mariel Coradin, Xiaoshi Wang, Kelly R. Karch, Chrystian Ruminowicz and Benjamin A. Garcia
    Citation: Epigenetics & Chromatin 2017 10:34
    Content type: Methodology Published on:

  45. Chromatin insulators shield promoters and chromatin domains from neighboring enhancers or chromatin regions with opposing activities. Insulator-binding proteins and their cofactors mediate the boundary functio...

    Authors: Theresa Jox, Melanie K. Buxa, Dorte Bohla, Ikram Ullah, Igor Mačinković, Alexander Brehm, Marek Bartkuhn and Rainer Renkawitz
    Citation: Epigenetics & Chromatin 2017 10:32
    Content type: Research Published on:

  46. Differential DNA methylation plays a critical role in the regulation of imprinted genes. The differentially methylated state of the imprinting control region is inherited via the gametes at fertilization, and ...

    Authors: Megan Guntrum, Ekaterina Vlasova and Tamara L. Davis
    Citation: Epigenetics & Chromatin 2017 10:31
    Content type: Research Published on:

  47. Heterogametic species display a differential number of sex chromosomes resulting in imbalanced transcription levels for these chromosomes between males and females. To correct this disequilibrium, dosage comp...

    Authors: Gautier Richard, Fabrice Legeai, Nathalie Prunier-Leterme, Anthony Bretaudeau, Denis Tagu, Julie Jaquiéry and Gaël Le Trionnaire
    Citation: Epigenetics & Chromatin 2017 10:30
    Content type: Research Published on:

  48. Melon (Cucumis melo) is an important vegetable crop from the Cucurbitaceae family and a reference model specie for sex determination, fruit ripening and vascular fluxes studies. Nevertheless, the nature and role ...

    Authors: David Latrasse, Natalia Y. Rodriguez-Granados, Alaguraj Veluchamy, Kiruthiga Gayathri Mariappan, Claudia Bevilacqua, Nicolas Crapart, Celine Camps, Vivien Sommard, Cécile Raynaud, Catherine Dogimont, Adnane Boualem, Moussa Benhamed and Abdelhafid Bendahmane
    Citation: Epigenetics & Chromatin 2017 10:22
    Content type: Research Published on:

  50. DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent sex determination (TSD) epitomizes phenotypic plasticity where environmental ...

    Authors: Srihari Radhakrishnan, Robert Literman, Beatriz Mizoguchi and Nicole Valenzuela
    Citation: Epigenetics & Chromatin 2017 10:28
    Content type: Research Published on:
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