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  1. Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. Th...

    Authors: Kenneth K Lee, Selene K Swanson, Laurence Florens, Michael P Washburn and Jerry L Workman
    Citation: Epigenetics & Chromatin 2009 2:2
    Content type: Research Published on:

  2. Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that sho...

    Authors: Maartje J Vogel, Ludo Pagie, Wendy Talhout, Marja Nieuwland, Ron M Kerkhoven and Bas van Steensel
    Citation: Epigenetics & Chromatin 2009 2:1
    Content type: Research Published on:

  3. Direct visualization of chromatin has the potential to provide important insights into epigenetic processes. In particular, atomic force microscopy (AFM) can visualize single nucleosomes under physiological io...

    Authors: Hongda Wang, Yamini Dalal, Steven Henikoff and Stuart Lindsay
    Citation: Epigenetics & Chromatin 2008 1:10
    Content type: Methodology Published on:

  4. The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks,...

    Authors: Christoffel Dinant, Adriaan B Houtsmuller and Wim Vermeulen
    Citation: Epigenetics & Chromatin 2008 1:9
    Content type: Review Published on:

  5. In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zy...

    Authors: Konstantin Lepikhov, Valeri Zakhartchenko, Ru Hao, Feikun Yang, Christine Wrenzycki, Heiner Niemann, Eckhard Wolf and Joern Walter
    Citation: Epigenetics & Chromatin 2008 1:8
    Content type: Research Published on:

  6. Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methyla...

    Authors: Ida LM Candiloro, Thomas Mikeska, Peter Hokland and Alexander Dobrovic
    Citation: Epigenetics & Chromatin 2008 1:7
    Content type: Methodology Published on:

  7. Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. Th...

    Authors: Asako J Nakamura, Y Jeffrey Chiang, Karen S Hathcock, Izumi Horikawa, Olga A Sedelnikova, Richard J Hodes and William M Bonner
    Citation: Epigenetics & Chromatin 2008 1:6
    Content type: Research Published on:

  8. Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa, a fungus that sports DNA methylation, ...

    Authors: Kristina M Smith, Gregory O Kothe, Cindy B Matsen, Tamir K Khlafallah, Keyur K Adhvaryu, Melissa Hemphill, Michael Freitag, Mohammad R Motamedi and Eric U Selker
    Citation: Epigenetics & Chromatin 2008 1:5
    Content type: Research Published on:

  9. Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution th...

    Authors: Xueying Wang, Zvi Kam, Peter M Carlton, Lifeng Xu, John W Sedat and Elizabeth H Blackburn
    Citation: Epigenetics & Chromatin 2008 1:4
    Content type: Research Published on:

  10. In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequence...

    Authors: Jan Postberg, Katharina Heyse, Marion Cremer, Thomas Cremer and Hans J Lipps
    Citation: Epigenetics & Chromatin 2008 1:3
    Content type: Research Published on:

  11. X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-co...

    Authors: Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager and Neil Brockdorff
    Citation: Epigenetics & Chromatin 2008 1:2
    Content type: Research Published on:
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Epigenetics & Chromatin

ISSN: 1756-8935