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  1. While the role of Polycomb group protein-mediated “cell memory” is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells. Emergin...

    Authors: Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef and Valerio Orlando
    Citation: Epigenetics & Chromatin 2019 12:78
  2. Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of ...

    Authors: Sylvia Garza-Manero, Abdulmajeed Abdulghani A. Sindi, Gokula Mohan, Ohoud Rehbini, Valentine H. M. Jeantet, Mariarca Bailo, Faeezah Abdul Latif, Maureen P. West, Ross Gurden, Lauren Finlayson, Silvija Svambaryte, Adam G. West and Katherine L. West
    Citation: Epigenetics & Chromatin 2019 12:73
  3. Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented re...

    Authors: Enrique M. Muro, Jonas Ibn-Salem and Miguel A. Andrade-Navarro
    Citation: Epigenetics & Chromatin 2019 12:72
  4. Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene i...

    Authors: Sidney H. Wang and Sarah C. R. Elgin
    Citation: Epigenetics & Chromatin 2019 12:70
  5. Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases...

    Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang and Ting Zhang
    Citation: Epigenetics & Chromatin 2019 12:69
  6. BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in SMARCA2, a BRM-encoding ...

    Authors: Iga Jancewicz, Janusz A. Siedlecki, Tomasz J. Sarnowski and Elzbieta Sarnowska
    Citation: Epigenetics & Chromatin 2019 12:68
  7. Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific...

    Authors: Alexandra V. Goodnight, Isaac Kremsky, Sujittra Khampang, Yoon Hee Jung, James M. Billingsley, Steven E. Bosinger, Victor G. Corces and Anthony W. S. Chan
    Citation: Epigenetics & Chromatin 2019 12:67
  8. Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It remains a ...

    Authors: Liduo Yin, Yanting Luo, Xiguang Xu, Shiyu Wen, Xiaowei Wu, Xuemei Lu and Hehuang Xie
    Citation: Epigenetics & Chromatin 2019 12:66
  9. In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retai...

    Authors: Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier and Tamara L. Davis
    Citation: Epigenetics & Chromatin 2019 12:64
  10. MeCP2—a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specifi...

    Authors: Alexia Martínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotchenko, Christoph H. Borchers, Erin M. Schuman, Matthias Zytnicki…
    Citation: Epigenetics & Chromatin 2019 12:63
  11. DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly unde...

    Authors: Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman and Assaf Zemach
    Citation: Epigenetics & Chromatin 2019 12:62
  12. Comparisons of Hi–C data sets between cell types and conditions have revealed differences in topologically associated domains (TADs) and A/B compartmentalization, which are correlated with differences in gene ...

    Authors: Lila Rieber and Shaun Mahony
    Citation: Epigenetics & Chromatin 2019 12:61
  13. Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider i...

    Authors: Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Heidi G. Sutherland, Nicole White, Daniel Kennedy, Kerry Mengersen, Larisa M. Haupt and Lyn R. Griffiths
    Citation: Epigenetics & Chromatin 2019 12:60
  14. The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA me...

    Authors: Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia and Yongguang Tao
    Citation: Epigenetics & Chromatin 2019 12:59
  15. Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification r...

    Authors: Niran Hadad, Dustin R. Masser, Laura Blanco-Berdugo, David R. Stanford and Willard M. Freeman
    Citation: Epigenetics & Chromatin 2019 12:58
  16. CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of ...

    Authors: Divyesh Patel, Manthan Patel, Subhamoy Datta and Umashankar Singh
    Citation: Epigenetics & Chromatin 2019 12:57
  17. Biofilm formation or flocculation is a major phenotype in wild type budding yeasts but rarely seen in laboratory yeast strains. Here, we analysed flocculation phenotypes and the expression of FLO genes in laborat...

    Authors: Hollie Rowlands, Kholoud Shaban, Barret Foster, Yannic Proteau and Krassimir Yankulov
    Citation: Epigenetics & Chromatin 2019 12:56
  18. Polycomb group (PcG) and trithorax group (trxG) proteins contribute to the specialization of cell types by maintaining differential gene expression patterns. Initially discovered as positive regulators of HOX ...

    Authors: Zain Umer, Jawad Akhtar, Muhammad Haider Farooq Khan, Najma Shaheen, Muhammad Abdul Haseeb, Khalida Mazhar, Aziz Mithani, Saima Anwar and Muhammad Tariq
    Citation: Epigenetics & Chromatin 2019 12:55
  19. Methylation of cytosines is an evolutionarily conserved epigenetic mark that is essential for the control of chromatin activity in many taxa. It acts mainly repressively, causing transcriptional gene silencing...

    Authors: Adéla Přibylová, Vojtěch Čermák, Dimitrij Tyč and Lukáš Fischer
    Citation: Epigenetics & Chromatin 2019 12:54
  20. TH2B is a major histone variant that replaces about 80–85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermato...

    Authors: Iyer Aditya Mahadevan, Satyakrishna Pentakota, Raktim Roy, Utsa Bhaduri and Manchanahalli R. Satyanarayana Rao
    Citation: Epigenetics & Chromatin 2019 12:53
  21. Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the ...

    Authors: Joanna Brühl, Jonathan Trautwein, Agnes Schäfer, Uwe Linne and Karim Bouazoune
    Citation: Epigenetics & Chromatin 2019 12:52
  22. The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches t...

    Authors: Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit and Wendy P. Robinson
    Citation: Epigenetics & Chromatin 2019 12:51
  23. The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyan...

    Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, Stacie K. Loftus and William J. Pavan
    Citation: Epigenetics & Chromatin 2019 12:50
  24. KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retr...

    Authors: Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger and Anne C. Ferguson-Smith
    Citation: Epigenetics & Chromatin 2019 12:49
  25. Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcripti...

    Authors: Vincent Pacini, Florence Petit, Bruno Querat, Jean-Noël Laverriere, Joëlle Cohen-Tannoudji and David L’hôte
    Citation: Epigenetics & Chromatin 2019 12:48
  26. A complex interplay between chromatin and topological machineries is critical for genome architecture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its m...

    Authors: Douglas Maya-Miles, Eloísa Andújar, Mónica Pérez-Alegre, Marina Murillo-Pineda, Marta Barrientos-Moreno, María J. Cabello-Lobato, Elena Gómez-Marín, Macarena Morillo-Huesca and Félix Prado
    Citation: Epigenetics & Chromatin 2019 12:47
  27. Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination and maintenance of cell identity. In macrophages, spec...

    Authors: Federica Ferri, Vanessa Petit, Vilma Barroca and Paul-Henri Romeo
    Citation: Epigenetics & Chromatin 2019 12:46
  28. Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes ...

    Authors: Eriko Oya, Mickaël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli and Karl Ekwall
    Citation: Epigenetics & Chromatin 2019 12:45
  29. Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream eff...

    Authors: Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann and Dustin E. Schones
    Citation: Epigenetics & Chromatin 2019 12:44
  30. While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven t...

    Authors: Candace J. Poole, Atul Lodh, Jeong-Hyeon Choi and Jan van Riggelen
    Citation: Epigenetics & Chromatin 2019 12:41
  31. In animals, H3K4me2 and H3K4me3 are enriched at the transcription start site (TSS) and function as epigenetic marks that regulate gene transcription, but their functions in plants have not been fully character...

    Authors: Yuhao Liu, Kunpeng Liu, Liufan Yin, Yu Yu, Ji Qi, Wen-Hui Shen, Jun Zhu, Yijing Zhang and Aiwu Dong
    Citation: Epigenetics & Chromatin 2019 12:40
  32. Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene tra...

    Authors: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes and P. Grandi
    Citation: Epigenetics & Chromatin 2019 12:39
  33. In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a gen...

    Authors: Anna Mallol, Maria Guirola and Bernhard Payer
    Citation: Epigenetics & Chromatin 2019 12:38
  34. The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer...

    Authors: Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake and Tilman Borggrefe
    Citation: Epigenetics & Chromatin 2019 12:37
  35. DamID, in which a protein of interest is fused to Dam methylase, enables mapping of protein-DNA binding through readout of adenine methylation in genomic DNA. DamID offers a compelling alternative to chromati...

    Authors: Tomasz Szczesnik, Joshua W. K. Ho and Richard Sherwood
    Citation: Epigenetics & Chromatin 2019 12:36
  36. Laryngeal squamous cell carcinoma (LSCC) is among the most common malignant tumors with poor prognosis. Accumulating evidences have identified the important roles of long noncoding RNAs (lncRNAs) in the initia...

    Authors: Baoshan Wang, Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui and Wenxia Meng
    Citation: Epigenetics & Chromatin 2019 12:35
  37. Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epig...

    Authors: Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans and Menno P. J. de Winther
    Citation: Epigenetics & Chromatin 2019 12:34
  38. Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ...

    Authors: Jane Gilmour, Leigh O’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen and Constanze Bonifer
    Citation: Epigenetics & Chromatin 2019 12:33
  39. TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho...

    Authors: Ting Zhang, Xiaowen Guan, Un Lam Choi, Qiang Dong, Melody M. T. Lam, Jianming Zeng, Jun Xiong, Xianju Wang, Terence C. W. Poon, Hongjie Zhang, Xuanjun Zhang, Hailin Wang, Ruiyu Xie, Bing Zhu and Gang Li
    Citation: Epigenetics & Chromatin 2019 12:32
  40. Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a...

    Authors: Louis Legoff, Ouzna Dali, Shereen Cynthia D’Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner and Fatima Smagulova
    Citation: Epigenetics & Chromatin 2019 12:29
  41. Localized functional domains within chromosomes, known as topologically associating domains (TADs), have been recently highlighted. In Drosophila, TADs are biochemically defined by epigenetic marks, this suggesti...

    Authors: Antony Lesage, Vincent Dahirel, Jean-Marc Victor and Maria Barbi
    Citation: Epigenetics & Chromatin 2019 12:28
  42. Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding tran...

    Authors: Yilin Zhao, Deyou Zheng and Ales Cvekl
    Citation: Epigenetics & Chromatin 2019 12:27
  43. Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multipl...

    Authors: Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham and David J. Segal
    Citation: Epigenetics & Chromatin 2019 12:26
  44. Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV...

    Authors: Chuan Li, Guillaume Mousseau and Susana T. Valente
    Citation: Epigenetics & Chromatin 2019 12:23

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