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  1. Chromatin insulators shield promoters and chromatin domains from neighboring enhancers or chromatin regions with opposing activities. Insulator-binding proteins and their cofactors mediate the boundary functio...

    Authors: Theresa Jox, Melanie K. Buxa, Dorte Bohla, Ikram Ullah, Igor Mačinković, Alexander Brehm, Marek Bartkuhn and Rainer Renkawitz

    Citation: Epigenetics & Chromatin 2017 10:32

    Content type: Research

    Published on:

  2. Differential DNA methylation plays a critical role in the regulation of imprinted genes. The differentially methylated state of the imprinting control region is inherited via the gametes at fertilization, and ...

    Authors: Megan Guntrum, Ekaterina Vlasova and Tamara L. Davis

    Citation: Epigenetics & Chromatin 2017 10:31

    Content type: Research

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  3. Heterogametic species display a differential number of sex chromosomes resulting in imbalanced transcription levels for these chromosomes between males and females. To correct this disequilibrium, dosage comp...

    Authors: Gautier Richard, Fabrice Legeai, Nathalie Prunier-Leterme, Anthony Bretaudeau, Denis Tagu, Julie Jaquiéry and Gaël Le Trionnaire

    Citation: Epigenetics & Chromatin 2017 10:30

    Content type: Research

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  4. Melon (Cucumis melo) is an important vegetable crop from the Cucurbitaceae family and a reference model specie for sex determination, fruit ripening and vascular fluxes studies. Nevertheless, the nature and role ...

    Authors: David Latrasse, Natalia Y. Rodriguez-Granados, Alaguraj Veluchamy, Kiruthiga Gayathri Mariappan, Claudia Bevilacqua, Nicolas Crapart, Celine Camps, Vivien Sommard, Cécile Raynaud, Catherine Dogimont, Adnane Boualem, Moussa Benhamed and Abdelhafid Bendahmane

    Citation: Epigenetics & Chromatin 2017 10:22

    Content type: Research

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  6. DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent sex determination (TSD) epitomizes phenotypic plasticity where environmental ...

    Authors: Srihari Radhakrishnan, Robert Literman, Beatriz Mizoguchi and Nicole Valenzuela

    Citation: Epigenetics & Chromatin 2017 10:28

    Content type: Research

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  7. The ubiquitin protein E3A ligase gene (UBE3A) gene is imprinted with maternal-specific expression in neurons and biallelically expressed in all other cell types. Both loss-of-function and gain-of-function mutatio...

    Authors: Paul R. Hillman, Sarah G. B. Christian, Ryan Doan, Noah D. Cohen, Kranti Konganti, Kory Douglas, Xu Wang, Paul B. Samollow and Scott V. Dindot

    Citation: Epigenetics & Chromatin 2017 10:27

    Content type: Research

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  9. Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established larg...

    Authors: Lenka Gahurova, Shin-ichi Tomizawa, Sébastien A. Smallwood, Kathleen R. Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R. Andrews, Taiping Chen and Gavin Kelsey

    Citation: Epigenetics & Chromatin 2017 10:25

    Content type: Research

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  10. Epigenome editing is expected to manipulate transcription and cell fates and to elucidate the gene expression mechanisms in various cell types. For functional epigenome editing, assessing the chromatin context...

    Authors: Masahiro Okada, Mitsuhiro Kanamori, Kazue Someya, Hiroko Nakatsukasa and Akihiko Yoshimura

    Citation: Epigenetics & Chromatin 2017 10:24

    Content type: Research

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  11. The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perce...

    Authors: John R. Edwards, Olya Yarychkivska, Mathieu Boulard and Timothy H. Bestor

    Citation: Epigenetics & Chromatin 2017 10:23

    Content type: Review

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  12. The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypot...

    Authors: Lisa M. McEwen, Alexander M. Morin, Rachel D. Edgar, Julia L. MacIsaac, Meaghan J. Jones, William H. Dow, Luis Rosero-Bixby, Michael S. Kobor and David H. Rehkopf

    Citation: Epigenetics & Chromatin 2017 10:21

    Content type: Research

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  13. The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping ...

    Authors: Ksenia Skvortsova, Elena Zotenko, Phuc-Loi Luu, Cathryn M. Gould, Shalima S. Nair, Susan J. Clark and Clare Stirzaker

    Citation: Epigenetics & Chromatin 2017 10:16

    Content type: Research

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  14. Exposure to environmental stressors during development may lead to latent and transgenerational adverse health effects. To understand the role of DNA methylation in these effects, we used zebrafish as a verteb...

    Authors: Jorke H. Kamstra, Liana Bastos Sales, Peter Aleström and Juliette Legler

    Citation: Epigenetics & Chromatin 2017 10:20

    Content type: Research

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  17. Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 vari...

    Authors: Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian and Yamini Dalal

    Citation: Epigenetics & Chromatin 2017 10:17

    Content type: Research

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  18. Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that th...

    Authors: Arnab Nayak, Anja Reck, Christian Morsczeck and Stefan Müller

    Citation: Epigenetics & Chromatin 2017 10:15

    Content type: Research

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  19. The compaction of DNA in chromatin in eukaryotes allowed the expansion of genome size and coincided with significant evolutionary diversification. However, chromatin generally represses DNA function, and mecha...

    Authors: Johannes Petrus Maree, Megan Lindsay Povelones, David Johannes Clark, Gloria Rudenko and Hugh-George Patterton

    Citation: Epigenetics & Chromatin 2017 10:14

    Content type: Research

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  20. Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmet...

    Authors: Sonia Heras, Katrien Smits, Catharina De Schauwer and Ann Van Soom

    Citation: Epigenetics & Chromatin 2017 10:13

    Content type: Research

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  21. Histone posttranslational modifications (PTMs) function to regulate chromatin structure and function in part through the recruitment of effector proteins that harbor specialized “reader” domains. Despite effor...

    Authors: Erin K. Shanle, Stephen A. Shinsky, Joseph B. Bridgers, Narkhyun Bae, Cari Sagum, Krzysztof Krajewski, Scott B. Rothbart, Mark T. Bedford and Brian D. Strahl

    Citation: Epigenetics & Chromatin 2017 10:12

    Content type: Research

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  22. In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins like heterochromatin-bi...

    Authors: Aristea Magaraki, Godfried van der Heijden, Esther Sleddens-Linkels, Leonidas Magarakis, Wiggert A. van Cappellen, Antoine H. F. M. Peters, Joost Gribnau, Willy M. Baarends and Maureen Eijpe

    Citation: Epigenetics & Chromatin 2017 10:11

    Content type: Research

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  23. Alpha thalassemia/mental retardation X-linked syndrome (ATR-X) is caused by a mutation at the chromatin regulator gene ATRX. The mechanisms involved in the ATR-X pathology are not completely understood, but may i...

    Authors: Laila C. Schenkel, Kristin D. Kernohan, Arran McBride, Ditta Reina, Amanda Hodge, Peter J. Ainsworth, David I. Rodenhiser, Guillaume Pare, Nathalie G. Bérubé, Cindy Skinner, Kym M. Boycott, Charles Schwartz and Bekim Sadikovic

    Citation: Epigenetics & Chromatin 2017 10:10

    Content type: Research

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  24. Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The ...

    Authors: Stephanie B. Hatch, Clarence Yapp, Raquel C. Montenegro, Pavel Savitsky, Vicki Gamble, Anthony Tumber, Gian Filippo Ruda, Vassilios Bavetsias, Oleg Fedorov, Butrus Atrash, Florence Raynaud, Rachel Lanigan, LeAnne Carmichael, Kathy Tomlin, Rosemary Burke, Susan M. Westaway…

    Citation: Epigenetics & Chromatin 2017 10:9

    Content type: Methodology

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  25. Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation of embryonic stem (ES) cells. However, the roles of repressive histone modifications such as trimethylated h...

    Authors: Benjamin L. Kidder, Gangqing Hu, Kairong Cui and Keji Zhao

    Citation: Epigenetics & Chromatin 2017 10:8

    Content type: Research

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  26. Defining how epigenetic information is established in the germline during fetal development is key to understanding how epigenetic information is inherited and impacts on evolution and human health and disease.

    Authors: Lexie Prokopuk, Jessica M. Stringer, Kirsten Hogg, Kirstin D. Elgass and Patrick S. Western

    Citation: Epigenetics & Chromatin 2017 10:7

    Content type: Research

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  27. Germline nuclear RNAi in C. elegans is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous...

    Authors: Natallia Kalinava, Julie Zhouli Ni, Kimberly Peterman, Esteban Chen and Sam Guoping Gu

    Citation: Epigenetics & Chromatin 2017 10:6

    Content type: Research

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  28. In the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of hist...

    Authors: Jie Lan, Konstantin Lepikhov, Pascal Giehr and Joern Walter

    Citation: Epigenetics & Chromatin 2017 10:5

    Content type: Research

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  29. Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of...

    Authors: Zac Chatterton, Brigham J. Hartley, Man-Ho Seok, Natalia Mendelev, Sean Chen, Maria Milekic, Gorazd Rosoklija, Aleksandar Stankov, Iskra Trencevsja-Ivanovska, Kristen Brennand, Yongchao Ge, Andrew J. Dwork and Fatemeh Haghighi

    Citation: Epigenetics & Chromatin 2017 10:4

    Content type: Research

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  30. In multicellular organisms, epigenome dynamics are associated with transitions in the cell cycle, development, germline specification, gametogenesis and inheritance. Evolutionarily, regulatory space has increa...

    Authors: Pavla Navratilova, Gemma Barbara Danks, Abby Long, Stephen Butcher, John Robert Manak and Eric M. Thompson

    Citation: Epigenetics & Chromatin 2017 10:3

    Content type: Research

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  31. Histones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from pr...

    Authors: Sara El Kennani, Annie Adrait, Alexey K. Shaytan, Saadi Khochbin, Christophe Bruley, Anna R. Panchenko, David Landsman, Delphine Pflieger and Jérôme Govin

    Citation: Epigenetics & Chromatin 2017 10:2

    Content type: Methodology

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  32. Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In con...

    Authors: Elior Rahmani, Liat Shenhav, Regev Schweiger, Paul Yousefi, Karen Huen, Brenda Eskenazi, Celeste Eng, Scott Huntsman, Donglei Hu, Joshua Galanter, Sam S. Oh, Melanie Waldenberger, Konstantin Strauch, Harald Grallert, Thomas Meitinger, Christian Gieger…

    Citation: Epigenetics & Chromatin 2017 10:1

    Content type: Methodology

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  33. The dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central i...

    Authors: Tobias A. Knoch, Malte Wachsmuth, Nick Kepper, Michael Lesnussa, Anis Abuseiris, A. M. Ali Imam, Petros Kolovos, Jessica Zuin, Christel E. M. Kockx, Rutger W. W. Brouwer, Harmen J. G. van de Werken, Wilfred F. J. van IJcken, Kerstin S. Wendt and Frank G. Grosveld

    Citation: Epigenetics & Chromatin 2016 9:58

    Content type: Research

    Published on:

    The Related Article to this article has been published in Nature Protocols 2018 13:BFnprot2017132

  34. Genome organization into subchromosomal topologically associating domains (TADs) is linked to cell-type-specific gene expression programs. However, dynamic properties of such domains remain elusive, and it is ...

    Authors: Malte Wachsmuth, Tobias A. Knoch and Karsten Rippe

    Citation: Epigenetics & Chromatin 2016 9:57

    Content type: Research

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  35. The Illumina 450k array has been widely used in epigenetic association studies. Current quality-control (QC) pipelines typically remove certain sets of probes, such as those containing a SNP or with multiple m...

    Authors: Shan V. Andrews, Christine Ladd-Acosta, Andrew P. Feinberg, Kasper D. Hansen and M. Daniele Fallin

    Citation: Epigenetics & Chromatin 2016 9:56

    Content type: Research

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  36. The ability to measure DNA methylation precisely and efficiently continues to drive our understanding of this modification in development and disease. Whole genome bisulfite sequencing has the advantage of the...

    Authors: Michael J. Ziller, Elena K. Stamenova, Hongcang Gu, Andreas Gnirke and Alexander Meissner

    Citation: Epigenetics & Chromatin 2016 9:55

    Content type: Methodology

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  38. Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated reg...

    Authors: Avinash Thakur, Sarah-Jayne Mackin, Rachelle E. Irwin, Karla M. O’Neill, Gareth Pollin and Colum Walsh

    Citation: Epigenetics & Chromatin 2016 9:53

    Content type: Research

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  39. The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET domain-catalysed methylation of H3K4. It is essential for normal embryonic de...

    Authors: Maaike Wiersma, Marianne Bussiere, John A. Halsall, Nil Turan, Robert Slany, Bryan M. Turner and Karl P. Nightingale

    Citation: Epigenetics & Chromatin 2016 9:52

    Content type: Research

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  40. Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, He...

    Authors: Jian-Jun Jiang, Le-Hua Cheng, Huan Wu, Yong-Han He and Qing-Peng Kong

    Citation: Epigenetics & Chromatin 2016 9:51

    Content type: Research

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  41. Although technological advances now allow increased tumor profiling, a detailed understanding of the mechanisms leading to the development of different cancers remains elusive. Our approach toward understandin...

    Authors: Suhn Kyong Rhie, Yu Guo, Yu Gyoung Tak, Lijing Yao, Hui Shen, Gerhard A. Coetzee, Peter W. Laird and Peggy J. Farnham

    Citation: Epigenetics & Chromatin 2016 9:50

    Content type: Research

    Published on:

  42. The robustness of ChIP-seq datasets is highly dependent upon the antibodies used. Currently, polyclonal antibodies are the standard despite several limitations: They are non-renewable, vary in performance betw...

    Authors: Michele Busby, Catherine Xue, Catherine Li, Yossi Farjoun, Elizabeth Gienger, Ido Yofe, Adrianne Gladden, Charles B. Epstein, Evan M. Cornett, Scott B. Rothbart, Chad Nusbaum and Alon Goren

    Citation: Epigenetics & Chromatin 2016 9:49

    Content type: Methodology

    Published on:

  43. A comprehensive assessment of the epigenetic dynamics in cancer cells is the key to understanding the molecular mechanisms underlying cancer and to improving cancer diagnostics, prognostics and treatment. By c...

    Authors: Michiel E. Adriaens, Peggy Prickaerts, Michelle Chan-Seng-Yue, Twan van den Beucken, Vivian E. H. Dahlmans, Lars M. Eijssen, Timothy Beck, Bradly G. Wouters, Jan Willem Voncken and Chris T. A. Evelo

    Citation: Epigenetics & Chromatin 2016 9:48

    Content type: Research

    Published on:

  44. During meiosis, the X and Y chromosomes are transcriptionally silenced. The persistence of repressive chromatin marks on the sex chromatin after meiosis initially led to the assumption that XY gene silencing ...

    Authors: Charlotte Moretti, Daniel Vaiman, Frederic Tores and Julie Cocquet

    Citation: Epigenetics & Chromatin 2016 9:47

    Content type: Research

    Published on:

  45. Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to altered m...

    Authors: Peggy Prickaerts, Michiel E. Adriaens, Twan van den Beucken, Elizabeth Koch, Ludwig Dubois, Vivian E. H. Dahlmans, Caroline Gits, Chris T. A. Evelo, Michelle Chan-Seng-Yue, Bradly G. Wouters and Jan Willem Voncken

    Citation: Epigenetics & Chromatin 2016 9:46

    Content type: Research

    Published on:

  46. Obesity has tremendous impact on the health systems. Its epigenetic bases are unclear. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, reg...

    Authors: Valerio Pazienza, Concetta Panebianco, Francesca Rappa, Domenico Memoli, Michela Borghesan, Sara Cannito, Asami Oji, Giuseppe Mazza, Domenico Tamburrino, Giuseppe Fusai, Rosario Barone, Giulia Bolasco, Francesc Villarroya, Joan Villarroya, Kiyotaka Hatsuzawa, Francesco Cappello…

    Citation: Epigenetics & Chromatin 2016 9:45

    Content type: Research

    Published on:

  47. In C. elegans, in order to equalize gene expression between the sexes and balance X and autosomal expression, two steps are believed to be required. First, an unknown mechanism is hypothesized to upregulate the X...

    Authors: Alyssa C. Lau, Kevin P. Zhu, Elizabeth A. Brouhard, Michael B. Davis and Györgyi Csankovszki

    Citation: Epigenetics & Chromatin 2016 9:44

    Content type: Research

    Published on:

  48. Chromatin proteins control gene activity in a concerted manner. We developed a high-throughput assay to study the effects of the local chromatin environment on the regulatory activity of a protein of interest....

    Authors: Laura Brueckner, Joris van Arensbergen, Waseem Akhtar, Ludo Pagie and Bas van Steensel

    Citation: Epigenetics & Chromatin 2016 9:43

    Content type: Methodology

    Published on:

  49. In epigenetic research, both the increasing ease of high-throughput sequencing and a greater interest in genome-wide studies have resulted in an exponential flooding of epigenetic-related data in public domai...

    Authors: SriGanesh Jammula and Diego Pasini

    Citation: Epigenetics & Chromatin 2016 9:42

    Content type: Methodology

    Published on:

  50. In mammals, tight regulation of cytosine methylation is required for embryonic development and cellular differentiation. The trans-acting DNA methyltransferases that catalyze this modification have been identifi...

    Authors: David H. Taylor, Chelsea M. McLean, Warren L. Wu, Alex B. Wang and Paul D. Soloway

    Citation: Epigenetics & Chromatin 2016 9:41

    Content type: Research

    Published on:

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Epigenetics & Chromatin

ISSN: 1756-8935