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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations

Fig. 2

Prediction of TADs in the POI2 region in the X chromosome, position of patients’ breakpoints, POI candidate genes, and gene expression levels in the POI2 region. Overview of cell type-invariant TADs and chromatin states in POI2 region and relative position of patients’ breakpoints (shown by patients’ number). Below, the candidate genes for ovarian function (black bars) harbored by disrupted TADs (FOXO4, POF1B, and DIAPH2) or neighboring TAD (FGF16). The arrow direction (up or down) indicates the direction of effect from the gene expression comparison between patients and controls (upregulated or downregulated)

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Epigenetics & Chromatin

ISSN: 1756-8935