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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations

Fig. 1

Study workflow. a Patients’ selection criteria. b Blood collection for DNA extraction and cell culture. c Breakpoint mapping by whole genome sequencing searching for chimeric reads and inserts. d Prediction of TAD disruption and screening of position effect candidate genes. e LCL establishment for chromatin crosslink and RNA extraction. f Transcriptome profiling using RNA-seq to leverage differentially expressed genes (DEGs). g Histone modification screening by ChIP-seq for epigenetic landscape assessment. BP breakpoint

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Epigenetics & Chromatin

ISSN: 1756-8935