Fig. 6

MMP-2 spreading into the bodies of active short genes a IGV genome browser snapshot of the FDFT1 and CTSB (Cathepsin B) genes that contain either a single sharp ProMMP2-3xHA peak at TSS or a broad region that extends from the TSS peak through the gene body, respectively (top tract). Other ChIP-Seq enrichment tracts for RNA PolII, DNA accessible regions (ATAC) and indicated histone H3 modifications are shown. The transcription start sites of protein coding genes (PC TSSs) and the ProMMP2-3xHA called peaks and identified broad regions are displayed (bottom). b The average RPKM ChIP-Seq signal intensities (y-axis) of the 5,889 ProMMP2-3xHA narrow peaks (red) and 870 broad peaks (blue), centered at transcription start site (TSS) and extending − 5/ + 10 kb (x-axis), were strikingly similar to that of the elongating form of RNA PolII (RNA PolII-S2P, bottom). c Violin plot comparing the log transformed average expression (transcripts per million (TPM), y-axis) of the 5889 ProMMP2-3xHA narrow peak genes (red) to the 870 broad peak genes (blue). A Wilcoxon rank sum test was used to determine statistical significance