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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes

Fig. 4

MMP-2 is specifically targeted to transcription start sites a Venn diagram showing overlap of ProMMP2-3xHA peaks within 1 kb of TSSs of all canonical protein coding genes. b Average peak profiles of the 6532 ProMMP2-3xHA peaks, RNA PolII and DNA accessible regions (ATAC) centered at TSSs. The hypothetical distribution of nucleosomes is depicted (top) over the ± 2 kb window (x-axis) versus average RPKM intensity (y-axis). c Heatmaps and average peak profiles of the RPKM intensity (y-axis) of ProMMP2-3xHA, RNA PolII, ATAC-Seq, H3K4me3 and H3K18ac centered at TSSs over a ± 2 kb window (x-axis). d Representative genome browser images of the ADSL gene. Distribution of ProMMP2-3xHA, RNA Pol II, ATAC-Seq and indicated H3 modification enrichments across the locus are displayed relative to the RPKM signal of each (y-axis). The ProMMP2-3xHA called peaks and TSSs are indicated (bottom)

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Epigenetics & Chromatin

ISSN: 1756-8935