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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas

Fig. 2

Features of partially and fully hypermethylated UMRs. A Length distribution of phUMRs and fhUMRs. B Genomic distribution of phUMRs and fhUMRs. C Percentage of phUMRs and fhUMRs overlap with CpG islands, CGI shores, CGI shelves and Open seas. D Average signal of histone modification for phUMRs and fhUMRs within ± 3 kb in normal brain tissue. E Diagram to show the definition of partial Hyper and flanking UMR in phUMRs. The border was determined by the hypermethylated CpGs among normal brain and IDH mutant glioma tissues. F Evolutionary conservation score of partial Hyper and flanking UMR. The p-value was tested using a two-tailed t-test. G Average signals of histone modification for phUMRs within ± 3 kb in normal brain and IDH mutant glioma tissues. Average ChIP-seq signals were scaled into 2 kb for partial Hyper and flanking UMRs, respectively

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