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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

Fig. 2

Volcano plot and pathway analysis of DMRs and DhMRs enriched in STZ vs control. A Volcano plot of the DMRs. Hyper-5mC regions (red) have 3744 peaks, hypo-5mC regions (green) have 1623 peaks, and a total of 5367 DMR peaks are shown. KEGG pathway analysis of the B hypermethylated gene body regions and C hypomethylated gene body regions. D Volcano plot of the DhMRs. Hyper-5hmC regions (red) had 547 peaks, and hypo-5hmC regions (green) had 322 peaks; a total of 869 DhMR peaks are shown. E KEGG pathway analysis of the hyperhydroxymethylated gene body regions. For KEGG pathway analysis on the y-axis enriched pathway and x-axis fold enrichment given, the size of the dot at the end of the bar represents the number of genes, and the color represents the level of significance

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Epigenetics & Chromatin

ISSN: 1756-8935