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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

Fig. 1

Genomic distribution of 5mC and 5hmC peaks in the LV tissue of control and diabetic rats. A Heat map of the genomic distribution of 5mC peaks relative to TSS. B Heat map of the genomic distribution of 5hmC peaks relative to TSS. C, D Distribution of DMRs in genomic elements that have increased (hyper-5mC) and decreased (hypo-5mC) methylation in LV of diabetic vs control rat, C overall distribution D according to CpG density. E, F Distribution of DhMRs in genomic elements with increased (hyper-5hmC) and decreased (hypo-5hmC) hydroxymethylation in the LV tissue of diabetic vs control rats. E Overall distribution F according to CpG density. The promoter regions are defined as 1 kb upstream of the TSS

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