Fig. 5
From: Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
A proposed working model of AMC complex in a comparison with PRC2. A In AMC complex, Caf1 senses unmodified histone H3K4, and Mrg15 may interact with di-methylated histone H3K36 in one nucleosome. Ash1 methylates histone H3K36 in the other nucleosome (substrate nucleosome, S). The function of the histone binding module (BRD/PHD/BAH) is not known (indicated with a question mark). B In PRC2 complex, Caf1 together with SUZ12 senses unmodified histone H3K4 in one nucleosome, and EED senses methylated histone H3K27 in the other nucleosome. The EZH2 catalytic subunit in PRC2 methylates histone H3K27 in a substrate nucleosome (S)