Fig. 7

Proposed Chromatin Remodeling Model for LH/hCG-induced Ovulation. During the antral follicle growth, the GCs display high levels of histone acetylation catalyzed by histone acetylation transferases (HATs) as well as active transcription in response to FSH. Once LH surge or hCG trigger, the nuclear translocation CK2α enhances HDAC2 phosphorylation, thereby deacetylating histones non-selectively. Meanwhile, LH/hCG induces ERK1/2 phosphorylation activation to induce histone acetylation by HATs at ovulation-specific genes