Fig. 5
From: Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
A subset of KDM5 interactors are implicated in neurodevelopmental disorders. A Overlap between human orthologs of Drosophila KDM5 interactors and genes associated with ASD using the SFARI database. S indicates syndromic ASD. Scores indicate confidence of causal association, with 1 indicating strongest link. B 26 candidate interacting proteins identified and their SFARI score. C 24 candidate interacting proteins were identified as being implicated in ID, ASD and/or schizophrenia using DBD. D Model for KDM5 interactions with key transcriptional proteins that are likely to impact the expression of downstream target genes