Fig. 6

Real data application: demonstration of dynamics of bipolar methylated loci from 2-week to 4-week stages in mouse brain methylome. Each dot represents the empirical relation of methylation entropy (OME) vs. mean methylation level (MML) in a CpG segment with at least 20× sequencing depth. Green dots show the identified bipolar methylated loci. Blue and black dots indicate respectively the absence and presence of spatial correlation decided by the proposed chi-square test. For comparison, the analytical relation between methylation entropy and methylation probability is shown in solid lines, with blue curve standing for no spatial correlation (\(r=0\)) and 10 black curves from top to bottom corresponding to spatial correlations from weak to strong (\(r=0.1,\,0.2,\,\ldots ,\,1\)). A OME vs. MML in the 2-week sample. B OME vs. MML in the 4-week sample