Fig. 15

Direct comparison of differential methylation and chromatin accessibility between E14.5 embryonic epithelium and newborn P0.5 fibers. A Numbers of differentially methylated and accessible regions and their associations with DEGs. B The top 20 gene ontology terms obtained from differentially methylated-accessible regions. C Five selected de novo enriched motifs in this differentiation path, hypomethylated DMRs, best match results for transcription factors recognizing these motifs, and enrichment p-values (brackets). For the full results of the de novo enriched motif analysis, see Additional file 9: Table S7. No significantly enriched de novo motifs were found for hypermethylated DMRs