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Fig. 12 | Epigenetics & Chromatin

Fig. 12

From: Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation

Fig. 12

DNA methylation, chromatin accessibility and Pax6-binding at the Pax6 and Prox1 loci in lens chromatin. A Pax6 locus, including Paupar (Pax6os1) and portion of Elp4. Two super-enhancer regions SE1 and SE2 are marked. Three regions of Pax6 binding, reduced methylation and open chromatin (boxed), 5′-distal region of Pax6 binding, high methylation and open chromatin of unknown function (green box), two regions of Pax6 binding, high methylation and closed chromatin (dashed boxes). B Prox1 locus. A region of Pax6 binding, reduced methylation and open chromatin (boxed), two regions of Pax6 binding, mostly closed chromatin and presence of DNA methylation (dashed boxes). The individual tracks include evolutionary conservation (cons) and DNA methylation (see Fig. 1), ATAC-seq (see Fig. 9) and Pax6-binding (newborn whole lens chromatin)

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