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Fig. 11 | Epigenetics & Chromatin

Fig. 11

From: Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation

Fig. 11

DNA Methylation and chromatin accessibility in Pax6 ChIP-seq peaks. A Profiles of DNA methylation in lens samples and chromatin accessibility via ATAC-seq in Pax6 peaks in newborn, sorted by regions of open chromatin in either epithelium or fiber and closed chromatin in both lens samples. Pax6 peaks appear in both open and closed chromatin, with the center of open chromatin regions showing demethylation overall. B Mean methylation within Pax6 peaks in representative epithelium and fiber samples. DNA Methylation within Pax6 peaks in the whole lens strongly correlated between epithelium and fiber. While Pax6 peaks concentrate towards regions showing low methylation in both epithelium and fiber, a significant number of peaks occupy regions with high methylation in both cell types

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Epigenetics & Chromatin

ISSN: 1756-8935