Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data

Table 1 Cohort demographics

	Female (XX)	Male (XY)	p-value*
N	309	325
Gestational age [weeks, mean (SD)]	39.43 (1.12)	39.46 (1.05)	0.663
Cohort (n)			0.770
EPIC^†	25	28
NHBC (GSE71678)	144	159
RICHS (GSE75248)	140	138
PlaNET ancestry
Coordinate 1	0.28 (0.21)	0.28 (0.18)	0.968
Coordinate 2	0.37 (0.25)	0.37 (0.21)	0.780
Coordinate 3	0.36 (0.25)	0.35 (0.22)	0.759

Demographics of the 634-sample cohort with Illumina Infinium HumanMethylation450 BeadChip data in IDAT format, used to evaluate effect of processing and analysis on X and Y chromosome DNAme signatures
^*p-values are from Fisher’s exact test for categorical variables and t-tests for continuous variables
^†EPIC normative term samples deposited in projects GSE100197, GSE108567, GSE98224, and GSE74738

ISSN: 1756-8935