Fig. 4

Investigating differential DNAme on the X and Y chromosome by acute chorioamnionitis status. A Manhattan plot of X chromosome CpGs tested for DNAme differences between acute chorioamnionitis and non-acute chorioamnionitis samples, with XX samples shown on top row and XY samples on bottom row. The horizontal grey intercept indicates FDR < 0.05, chrX hg19 coordinates are shown along the X axis. B Manhattan plot of Y chromosome CpGs tested for DNAme differences between acute chorioamnionitis and non-acute chorioamnionitis XY male placental samples. The horizontal grey intercept indicates FDR < 0.05, chrY hg19 coordinates are shown along the X axis. C Distribution of DNAme β values for acute chorioamnionitis-affected (aCA) versus unaffected (non-aCA) placental samples at the NKAP X chromosomal locus (cg22880666). At FDR < 0.05, this CpG was significantly differentially methylated by aCA status