Table 1 Dibutyl-phthalate (DBP) responsive Chromatin remodeler cofactors, RNA interactors, Readers, Erasers, and Writers (CRREWs)

CUL2

Chromatin remodeler cofactor

Yes

Full-length

chr10_35049683_35049765

73.34378112

B₁HB₂

Full-length

chr10_35071199_35071339^a

45.88953277

36.94494826

33.3796977

Down—same

chr10_35054434_35054539

90.27970798

chr10_35060874_35060968

124.36174959

H₁BH₂

Full-length

chr10_35031300_35031386

10.9300058

12.60999224

16.5514561

Up—up

chr10_35062960_35063062

76.39002731

EFCAB6

Chromatin remodeler cofactor

Yes

Full-length

chr22_43755766_43755832

47.99058386

H₁BH₂

Full-length

chr22_43808995_43809131^b

23.04421341

22.47121388

30.92004033

Same—up

FBRS

Chromatin remodeler cofactor

No

Full-length

chr16_30661180_30661215

139.16671978

H₁BH₂

Full-length

chr16_30665035_30665079^a

11.7002433

23.79308874

13.77795832

Up—same^c

chr16_30661304_30661333

163.82992422

chr16_30662420_30662468

322.18875278

chr16_30665306_30665401^a

15.91554696

33.45144483

17.72288399

Up—same^c

chr16_30668772_30668979

38.16171231

chr16_30665411_30665530^b

25.49395297

12.03010593

22.8260116

Same -up^c

FUS

RNA interactor

Yes

Full-length

chr16_31189665_31189794

90.62018963

B₁HB₂

Full-length

chr16_31179681_31179790^a

17.54623506

8.059807977

9.112771891

Down -same

PHF10

Chromatin remodeler cofactor

No

Full-length

chr6_169703905_169704088

56.77073068

B₁HB₂

Full-length

chr6_169712386_169712539^a

104.6714394

73.28088898

72.69274424

Down—same^c

chr6_169717742_169717906^b

26.5058166

21.75793957

28.02153713

Same -up^c

H₁BH₂

Full-length

chr6_169715708_169715857^b

46.4094406

41.91086488

25.73117816

Same—down^c

chr6_169715266_169715305^b

9.913662168

3.92151334

12.24840542

Same—up^c

TP53BP1

Reader

No

Full-length

chr15_43438324_43438416

60.10469689

B₁HB₂

Full-length (≥ 1 < 35 samples)

chr15_43491669_43491753^a

90.52982404

57.56060158

54.69346007

Down—same^c

chr15_43474673_43474767^a

43.09581869

24.32817473

22.95757362

Down—same^c

chr15_43477593_43477759^b

19.25400217

11.49681526

12.46340685

Same—up^c

ACTB

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr7_5529161_5529400

608.1603759

B₁HB₂

Fail

chr7_5527147_5527891^a

9.927226458

39.23923731

76.15182438

Up—same

chr7_5529535_5529663

160.4580747

ASXL3

Chromatin remodeling cofactor

Yes

Full-length (≥ 1 < 7 samples)

chr18_33607594_33607676^d

126.69565505

H1BH2

Fail

chr18_33605537_33605658^b

49.02305219

57.68603612

29.20425494

Same—down

chr18_33607594_33607676^{b, d}

100.1024646

122.0676208

65.30310662

ATXN7

Chromatin remodeling cofactor

No

Full-length

chr3_63913157_63913225

23.23374838

B1HB2

Full-length (≥ 1 < 35 samples)

chr3_63971410_63971449^a

44.13861655

18.85341672

31.88951213

Down—up^c

chr3_63952379_63952483

65.56893528

chr3_63970990_63971199^a

28.29537781

16.13056589

15.78642347

Down—same^c

chr3_63979915_63980167

65.82895373

chr3_63970590_63970729^a

28.9651738

31.0349008

22.84394278

chr3_63982186_63982445

51.9743582

chr3_63982939_63983021

86.70154882

H1BH2

Full-length (≥ 1 < 55 samples)

chr3_63990176_63990374^a

15.20540033

23.06433484

18.39674764

Up—same

chr3_63988059_63988324

86.65469577

chr3_63997621_63997687

20.627258

BRD2

Reader

No

Full-length (≥ 1 < 7 samples)

chr6_32974462_32974765^d

167.2971302

B1HB2

Full-length (≥ 1 < 35 samples)

chr6_32974462_32974765^{a, d}

148.0520041

95.59297034

97.45927523

Down—same

chr6_32975384_32975521

244.581243

chr6_32976031_32976169

246.1430444

chr6_32976250_32976464

449.0591325

chr6_32978126_32978388

290.1415452

chr6_32975021_32975112^a

88.41784757

53.73315186

53.689177

chr6_32979828_32980132

215.4520379

chr6_32980342_32980464

246.6401318

CBX8

Reader

No

Full-length (≥ 1 < 7 samples)

chr17_79796250_79796315

109.1088811

B1HB2

Full-length (≥ 1 < 35 samples)

chr17_79796497_79796540^a

67.72774064

35.94307833

47.37031239

Down—same

CUL4A

Writer

Yes

Full-length (≥ 1 < 7 samples)

chr13_113245152_113245237^d

45.83401639

H1BH2

Fail

chr13_113245152_113245237^{b, d}

4.749607197

11.83695093

4.810742772

Same—down

DDX21

RNA interactor

No

Full-length (≥ 1 < 7 samples)

chr10_68956077_68956312

45.59930818

B1HB2

Full-length (≥ 1 < 35 samples)

chr10_68973545_68973664^a

12.48308777

6.652350194

6.801472421

Down—same

chr10_68956128_68956312

58.23824687

chr10_68959806_68960249

27.30981821

DDX5

Chromatin remodeling cofactor

No

Full-length

chr17_64499616_64500326

50.18733594

H1BH2

Full-length (≥ 1 < 55 samples)

chr17_64508057_64508199^a

18.07129807

31.49088399

21.44690173

Up—same

chr17_64502439_64502549

222.7743864

chr17_64502926_64503098

174.5232727

chr17_64504677_64504842

562.365823

EYA3

Eraser

No

Full-length (≥ 1 < 7 samples)

chr1_28035544_28035680

40.65905966

B1HB2

Full-length (≥ 1 < 35 samples)

chr1_27989697_27989811^a

17.51387147

8.11829011

7.684114697

Down—same

chr1_28038839_28038905

71.9858758

chr1_28042571_28042650^d

82.19180154

chr1_28048383_28048426

55.11261243

H1BH2

Full-length (≥ 1 < 55 samples)

chr1_28042571_28042650^{b, d}

89.90445658

77.74204547

93.81864264

Same—up

chr1_28057994_28058094

55.29632114

FBL

Writer

No

Full-length (≥ 1 < 7 samples)

chr19_39834668_39834813

60.41931957

H1BH2

Fail

chr19_39839859_39839958^b

18.59527254

27.37708055

9.213151401

Same—down

chr19_39840233_39840327

50.69038934

FOXP1

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr3_71041328_71041532^d

42.11617683

H1BH2

Fail

chr3_71041328_71041532^{b, d}

15.6839618

13.71369054

15.54280611

Same—up

FOXP4

Chromatin remodeling cofactor

No

Fail

chr6_41587793_41587897

39.27112581

B1HB2

Fail

chr6_41591221_41591322^a

45.87619906

26.85038148

20.82985849

Down—same

chr6_41597176_41597242

144.390806

FTO

Eraser

No

Fail

chr16_53873786_53873865

21.75113943

B1HB2

Fail

chr16_54055231_54055250^a

69.62113525

20.61269425

18.47722558

down—same

GLYR1

Reader

No

Fail

chr16_4822875_4822931

85.08743926

H1BH2

Fail

chr16_4845074_4845153^{b, d}

36.46972236

46.9269976

20.87481521

Same—down

chr16_4832774_4832912

56.47345151

chr16_4846174_4846210^{b, d}

67.90414093

142.7455894

36.28550649

chr16_4845074_4845153^d

86.16449545

chr16_4847228_4847342^b

18.02496292

35.7298856

10.55306118

chr16_4846174_4846210^d

214.7925019

GSK3B

Writer

No

Full-length

chr3_119863419_119863605

47.57577249

B1HB2

Full-length (≥ 1 < 35 samples)

chr3_119947268_119947351^{a, d}

9.469777621

4.330235615

3.812284788

Down—same

chr3_119876413_119876508

74.65344499

chr3_119905755_119905852

40.17183664

chr3_119947268_119947351^d

8.201198964

HDGF

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr1_156742107_156743455

29.31885782

B1HB2

Full-length (≥ 1 < 35 samples)

chr1_156746941_156747070^a

38.46470389

21.80162743

33.42011021

Down—up

chr1_156745008_156745146

103.5140225

chr1_156745297_156745373

153.7851866

JAK2

Writer

No

Fail

chr9_5044403_5044520

73.43333397

B1HB2

Fail

chr9_5093247_5093296^a

20.58490527

32.01820286

32.69512962

Up—same

chr9_5050686_5050831

107.4942939

chr9_5054563_5054884

130.4274597

chr9_5064883_5065040

25.21798197

chr9_5066678_5066789

24.52971222

chr9_5069022_5069208

21.28614607

chr9_5072492_5072626

14.53980654

JMJD1C

Eraser

No

Full-length

chr10_63215263_63215455

35.51650661

B1HB2

Full-length (≥ 1 < 35 samples)

chr10_63380318_63380482^b

17.4600717

19.05969651

18.90688543

Same—up

KDM3B

Eraser

No

Full-length (≥ 1 < 7 samples)

chr5_138381516_138381590

46.44162202

B1HB2

Fail

chr5_138381516_138381748^a

12.66998754

4.873031368

7.239254403

Down—same

METTL14

Writer

No

Full-length

chr4_118689370_118689457

123.1705451

B1HB2

Full-length (≥ 1 < 35 samples)

chr4_118694436_118694526^{a, d}

83.51980054

46.03741119

51.4908201

Down—same

chr4_118691981_118692068

31.29652938

chr4_118694436_118694526^d

64.94446923

chr4_118703935_118704051

25.19397513

NCL

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr2_231455378_231455397

102.5438988

B1HB2

Fail

chr2_231461540_231462017^a

5.236450253

20.29187093

12.3903226

Up—same

chr2_231455401_231455624

67.46658314

PBK

Writer

No

Fail

chr8_27833056_27833133

84.32665353

B1HB2

Fail

chr8_27822319_27822488^a

29.13220667

13.70207793

20.37717724

Down—same

PHC3

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr3_170136419_170136665

47.04021032

B1HB2

Fail

chr3_170136366_170136670^b

33.10320015

23.37991969

38.36697809

Same—up^c

chr3_170125959_170126008^{b, e}

50.56724341

47.14446851

39.30243571

Same—down^c

chr3_170145423_170145521

43.83520446

H1BH2

Full-length (≥ 1 < 55 samples)

chr3_170125959_170126008^{b, e}

52.42505534

68.67472239

68.63626944

Up—same

PIAS2

Chromatin remodeling cofactor

Yes

Full-length (≥ 1 < 7 samples)

chr18_46829734_46829867

126.9338048

H1BH2

Full-length (≥ 1 < 55 samples)

chr18_46864164_46864248^b

22.18313576

34.11708408

15.93112434

Same—down

chr18_46890580_46891054

94.25493752

PKM

Writer

Yes

Full-length

chr15_72199029_72199756

209.0372187

H1BH2

Full-length (≥ 1 < 55 samples)

chr15_72218943_72219110^b

227.6530273

228.3467372

257.298983

Same—up

chr15_72202454_72202620

90.41567139

chr15_72203022_72203188

104.69183

chr15_72206728_72206880

186.5303306

chr15_72207127_72207277

114.0294777

chr15_72208621_72208891

435.9339603

chr15_72221168_72221284^b

509.0236626

472.2128562

505.8016084

chr15_72209673_72209859

216.5984929

chr15_72210347_72210478

202.6510004

chr15_72217409_72217500

179.5251466

chr15_72218944_72219110

477.2075803

PRDM2

Writer

No

Full-length (≥ 1 < 7 samples)

chr1_13731000_13731117

24.97864201

B1HB2

Fail

chr1_13732779_13732882^{a, d}

18.88791629

10.83481881

12.63840862

Down—same

chr1_13732779_13732882^d

37.83172965

RAD23B

Chromatin remodeling cofactor

No

Full-length

chr9_107300141_107300222

148.4985198

B1HB2

Full-length

chr9_107284227_107284516^b

135.0056956

108.3285612

102.4563633

Same—up

chr9_107302035_107302114

358.8938006

chr9_107306379_107306647

179.2885343

chr9_107318752_107318879

199.0418759

chr9_107321983_107322118

194.6844742

chr9_107323890_107324017

157.6747147

chr9_107324834_107325004

166.7800603

RARA

Chromatin remodeling cofactor

No

Full-length

chr17_40348316_40348464

264.966321

H1BH2

Full-length

chr17_40352566_40352785^a

16.33385634

26.58279889

13.14358956

Up—same

RNF168

Writer

No

Full-length

chr3_196475231_196475312

48.87929838

B1HB2

Full-length

chr3_196499399_196499448^a

15.55914629

1.041898901

5.470952467

Down—same

chr3_196483770_196483891

241.4196715

chr3_196487399_196487578

559.0102154

chr3_196488607_196488683

281.9957217

RUVBL2

Chromatin remodeling cofactor

No

Fail

chr19_49007302_49007368

59.04042657

B1HB2

Full-length (≥ 1 < 35 samples)

chr19_49014484_49014603^b

47.65755052

13.18043333

33.28447611

Same—up

chr19_49009776_49009882

35.42102967

chr19_49011192_49011310^b

53.64749641

15.75904163

35.37293219

SET

Chromatin remodeling cofactor

No

Full-length (≥ 1 < 7 samples)

chr9_128691170_128691227

90.43894815

H1BH2

Full-length (≥ 1 < 55 samples)

chr9_128691837_128691856^a

156.10463

270.2214865

292.7547895

Up—same

chr9_128691858_128692000^d

72.31913227

chr9_128691858_128692000^{a, d}

42.4648848

65.60493112

83.79094344

chr9_128693896_128694042

151.4424237

SF1

RNA interactor

No

Full-length (≥ 1 < 7 samples)

chr11_64764606_64766155

26.12431153

B1HB2

Full-length (≥ 1 < 35 samples)

chr11_64769426_64769669^a

172.4290602

119.3861192

127.4741581

Down—up

chr11_64768106_64768286

481.6714801

chr11_64769022_64769129

287.9247696

chr11_64769223_64769338^d

347.3117268

chr11_64769223_64769338^{a, d}

268.8584151

177.0664881

189.0964138

chr11_64769426_64769609

282.135809

chr11_64769964_64770053^d

189.6875959

chr11_64770256_64770408

285.8362465

chr11_64769964_64770053^{b, d}

263.9851006

166.8656433

179.5980223

chr11_64773430_64773505

81.68394169

chr11_64776498_64776626

547.7503902

SMARCC1

Chromatin remodeling cofactor

No

Full-length

chr3_47622207_47622341^d

96.91272122

B1HB2

Full-length

chr3_47622207_47622341^{a, d}

69.77555281

82.07564582

58.44521961

Up—same^c

chr3_47635190_47635344^d

101.6629144

chr3_47765620_47765659^a

109.4318057

60.44008143

77.52801638

Down—same^c

chr3_47636022_47636136

211.0242123

chr3_47693241_47693300

161.5219186

chr3_47635190_47635344^{b, d}

68.84826131

67.34912737

52.97551238

Same—up^c

chr3_47701278_47701402

293.2391371

chr3_47706409_47706530

354.2425594

chr3_47714415_47714490^b

79.49924111

65.37542844

51.74915032

Same—down^c

chr3_47710683_47710808

239.6062289

H1BH2

Full-length

chr3_47638725_47638780^a

164.273275

199.1667454

152.0656841

Up—same

chr3_47729025_47729094

108.5173138

chr3_47736034_47736126

318.1530337

chr3_47738029_47738110

551.5659307

chr3_47745908_47745993

250.9244825

chr3_47772817_47772936

90.04905398

TLE4

Chromatin remodeling cofactor

No

Full-length

chr9_79573689_79573786

81.6334674

B1HB2

Full-length (≥ 1 < 35 samples)

chr9_79592157_79592236^b

467.4843202

474.343387

262.241103

Same—down

chr9_79652593_79652794

123.9598518

chr9_79704783_79704902

79.65856586

chr9_79705889_79705942

308.2412894

chr9_79706747_79706899

197.0445962

chr9_79708118_79708250

82.17201832

chr9_79722959_79723035

41.67603336

TRIM28

Reader

No

Full-length (≥ 1 < 7 samples)

chr19_58547792_58547906

62.21120415

B1HB2

Full-length (≥ 1 < 35 samples)

chr19_58547135_58547511^a

17.9583947

11.84868698

12.65668525

Down—same

TRMT5

Writer

No

Full-length

chr14_60975475_60976126^d

112.849635

B1HB2

Full-length

chr14_60975475_60976126^{a, d}

162.1052502

126.0231338

104.0717295

Down—same

chr14_60977514_60977638

181.1539029

chr14_60979231_60979886

238.7932734

YBX1

RNA interactor

No

Full-length (≥ 1 < 7 samples)

chr1_42683403_42683466

112.849635

H1BH2

Full-length (≥ 1 < 55 samples)

chr1_42693490_42693523^a

15.04921986

16.15993097

18.42589961

Up—same

YWHAZ

Reader

No

Full-length

chr8_100916525_100920752

18.15976034

B1HB2

Full-length

chr8_100952850_100953057^a

7.347282187

9.551674351

6.886102163

Up—same

chr8_100924135_100924298

110.0538877

chr8_100924916_100925039

162.8023477

chr8_100951929_100952129

82.9444817

ZNF541

Chromatin remodeling cofactor

No

Fail

chr19_47521479_47521654

7.42074551

H₁BH₂

Fail

chr19_47521854_47521994^a

20.03276583

10.73806747

14.37279423

Down—same