Fig. 6

Postnatal development and phenotype of SRS model mice. a Appearance of TG and Non-TG mice at 5 weeks. b Growth retardation of male TG mice continued to be observed at 5 weeks. c Food intake (g/day) was examined in male TG and Non-TG mice (3 weeks). d H19-DMR methylation status in the liver at 5 weeks analyzed by COBRA. TG mice showed frequent demethylation. e Glucose tolerance and f insulin tolerance tests in TG and Non-TG male mice (4 and 5 weeks, respectively) fed normal chow were performed after an overnight fast. Blood glucose concentration tended to be lower in TG mice. g TG mice (2/3) showed fibrosis in cardiac muscle fiber by Masson's trichrome stain, whereas this phenotype was not observed in non-TG mice (0/3). Scale bar, 100 μm. Error bars, mean ± s.d. *P < 0.05, **P < 0.01, n.s. not significant (two-tailed Student’s t test)