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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model

Fig. 3

Transcription alteration and recovery following NaBut treatment. A Heat map showing genes significantly altered over the time-course of the treatment. Non-treated (Nt1, Nt2, Nt3, Nt10) and NaBut-treated (NaBut1, NaBut2, NaBut3, NaBut10) spheroids, treated for 1, 2, or 3 days and the recovery time point (day 10); n = 3. B Average trajectory of genes over the time-course for each cluster showing return to baseline levels at recovery time point (day 10). Ribbons represents standard error. C Gene ontology biological process over-representation analysis for each of the clusters. D Cell-type signature over-representation analysis for each of the clusters. Clusters A–D are downregulated and clusters E–H are upregulated over the time-course

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Epigenetics & Chromatin

ISSN: 1756-8935