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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin

Fig. 6

Cohesin-mediated loops at CTCF convergent sites. Speculative model showing how a single cohesin complex could be arrested at the base of a chromatin loop with CTCF to motifs in convergent orientation. The N-terminal region of the CTCF molecule on the left would interact with PDS5 while the one on the right would bind the STAG/RAD21 interface. PDS5 binding to RAD21 would prevent the interaction with NIPBL, halting extrusion, while WAPL interactions with PDS5 and STAG/RAD21 would be also precluded, blocking release of the complex. Acetylation of SMC3 head (Ac) would strengthen the cohesin–PDS5 interaction

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Epigenetics & Chromatin

ISSN: 1756-8935