Skip to main content

Table 2 Distributions of maternal and fetal participant and sample characteristics for those with placenta DNA methylation measures, split by maternal use of prenatal vitamins in month 1 of pregnancy

From: Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts

 

MARBLES

EARLI

 

No use of prenatal vitamins month 1

Use of prenatal vitamins month 1

P-value

No use of prenatal vitamins month 1

Use of prenatal vitamins month 1

P-value

 

N = 37

N = 33

 

N = 35

N = 53

 

Maternal education

 No degree

21 (56.8%)

10 (30.3%)

0.05

17 (48.6%)

19 (35.8%)

0.33

 College degree

16 (43.2%)

23 (69.7%)

18 (51.4%)

34 (64.2%)

Maternal age at delivery (years)

35.3 (5.16)

35.1 (5.86)

0.89

33.8 (4.46)

33.5 (4.75)

0.77

Maternal pre-pregnancy BMI

29.0 (8.21)

26.4 (5.86)

0.12

26.8 (5.90)

27.9 (8.20)

0.47

Child race/ethnicity

 Non-Hispanic White

16 (43.2%)

8 (24.2%)

0.11

16 (45.7%)

25 (47.2%)

0.34

 Hispanic

14 (37.8%)

12 (36.4%)

 

5 (14.3%)

11 (20.8%)

 

 Other/multiple

7 (18.9%)

13 (39.4%)

 

14 (40.0%)

17 (32.1%)

 

Child sex

 Female

17 (45.9%)

7 (21.2%)

0.05

18 (51.4%)

17 (32.1%)

0.11

 Male

20 (54.1%)

26 (78.8%)

 

17 (48.6%)

36 (67.9%)

 

Gestational age at delivery (weeks)

39.4 (1.14)

39.2 (0.83)

0.49

39.1 (1.59)

39.4 (1.22)

0.39

Estimated cell proportion

 Trophoblasts

14.0 (7.55)

15.2 (6.14)

0.47

13.0 (6.04)

14.4 (5.13)

0.27

 Stromal

9.06 (6.41)

10.0 (6.26)

0.52

10.3 (3.75)

9.47 (3.51)

0.31

 Hofbauer

4.71 (2.22)

4.24 (2.22)

0.37

2.73 (1.45)

2.77 (1.54)

0.89

 Endothelial

5.43 (2.22)

7.25 (3.68)

0.02

5.57 (2.45)

6.05 (2.63)

0.38

 nRBC

0.80 (1.05)

0.55 (1.02)

0.32

1.24 (1.00)

1.46 (2.11)

0.51

 Syncytiotrophoblast

66.0 (12.6)

62.8 (9.74)

0.23

67.1 (9.18)

65.9 (8.63)

0.51

Mean DNA methylation

 Overall

53.3 (1.09)

52.8 (1.12)

0.05

45.0 (1.04)

44.5 (1.15)

0.03

 Open sea

65.3 (1.41)

64.7 (1.49)

0.06

62.1 (1.17)

61.6 (1.48)

0.09

 CpG shelf

69.2 (1.26)

68.5 (1.50)

0.06

68.4 (1.29)

67.8 (1.61)

0.11

 CpG shore

45.5 (1.12)

45.0 (1.09)

0.06

42.7 (1.17)

42.1 (1.14)

0.02

 CpG island

18.7 (0.69)

18.6 (0.70)

0.64

20.1 (1.00)

19.6 (0.92)

0.02

DNA methylation laboratory batch1

 1

–

–

–

32 (91.4%)

46 (86.8%)

0.73

 2

3 (8.57%)

7 (13.2%)

  1. 1The EARLI and MARBLES samples were run separately. In EARLI placenta batch represents two different runs, MARBLES placenta were measured in a single run on single plate