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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: 3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk

Fig. 6

Enrichment of gnomAD 3DFAACTS SNPs (left panel) and their interacting regions (right panel) found within NIH Epigenomics Roadmap samples. Enrichment test of filtered gnomAD SNPs against chromHMM states from 129 tissues and cell types from Epigenomics Roadmap using GIGGLE [87]. Green coloured regions indicate positive enrichment of variants within cell types and chromHMM states, while purple-coloured regions indicate negative enrichment. Here we subset to enrichment in three tissue groups, including thymus, HSC and B cell and blood and T cell, enrichment results of all samples can be found in Additional file 1: Fig. S14 and S15

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