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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: 3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk

Fig. 2

Visualisation of the CTLA4 region of filtered T1D SNPs on chr2: 203335966–204335966. Tracks displayed below the chromosome 2 ideogram display workflow datasets (3DFACCTS-SNP filtered SNPs, FOXP3-binding sites, Treg ATAC-seq peaks, statistically significant Hi-C interactions in Tregs (5 kb resolution), promoter and enhancer annotation) along with cell type-specific data including UCSC Gene Transcript information, T cell subsets (Thelper1 and Treg) expression data, super-enhancer data, 15-state ChromHMM track of T cell lineages. A heatmap showing the Tregs Hi-C interaction matrix (20 kb resolution) is located below the tracks. The plotted region of the tracks (chr22: 203335966–204335966) is indicated by the green area in the heatmap. The red triangles indicate topologically associated domains (TADs) called from the Hi-C interaction data

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