Fig. 1

Diagram of the individual components of the Treg-specific 3DFAACTS-SNP filtering workflow for identifying variants that are potentially causative to type 1 diabetes (T1D). GWAS or fine-mapped variants (on the left) are intersected with different filtering elements, including Treg ATAC-seq peaks, interactions from Treg Hi-C, promoters or enhancers and previously identified FOXP3 binding regions in Treg cells [28], resulting in filtered variants we termed 3DFAACTS SNPs