DNA methylation may affect beef tenderness through signal transduction in Bos indicus

Table 1 DMCs and DMRs that presented high correlation (Pearson; p-value < 0.05) between methylation level and gene expression of their predicted targets

DM	CpGi	Regulatory element state		Target gene^§	r	p
DM	CpGi	Muscle	Adipose	Target gene^§	r	p
DMC12	Other	ATAC island	Medium enhancer with ATAC	EPCAM	− 0.64	0.033
DMC98	Other	Quiescent	Quiescent	PDE4B	− 0.63	0.038
DMC23	CpGi	Bivalen/poised TSS	Strongly active promoter/transcript	GNAS	0.75	0.0085
DMC89	CpGi	strongly active promoters/transcripts	Bivalent/poised TSS	EBF3	− 0.72	0.013
DMC90	CpGi	strongly active promoters/transcripts	Bivalent/poised TSS	EBF3	− 0.75	0.0073
DMR40	CpGi	strongly active promoters/transcripts	Bivalent/poised TSS	EBF3	− 0.81	0.0023

The table includes whether the DMC or DMR overlaps a CpG island (CpGi), the regulatory element overlapped by the DMC or DMR in muscle and adipose tissues of Bos taurus, the target gene and the statistical association analysis results

ISSN: 1756-8935