Fig. 5
From: Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Chd4 genome-wide chromatin binding profile and analysis. A Heatmaps showing Chd4 occupancy centered in transcription start site (TSS) for all genes. The left and right panel correspond to heatmaps obtained from enriched spermatogonia fractions and whole 7 dpp testis, respectively. B Examples of Chd4 occupancy at or near dmrt1 promoter assessed by ChIP-seq. The top and bottom panels correspond to profiles obtained from enriched spermatogonia fractions and whole 7 dpp testis, respectively. C Pie chart depicting genomic features associated with Chd4 peaks. D Gene ontology analysis of genes associated to Chd4 ChIP-seq signals. E RT-PCR analysis for dmrt1 expression at exon 4–5 boundary in wild type and chd4 knockout testis