Fig. 6

H3.3K27M DIPG cells have accessible super-enhancers linked to increased gene expression compared to isogenic H3.3-WT DIPG samples. a Select super-enhancers of interest with open chromatin according to ATAC-seq data and increased gene expression via Tag-seq ranked according to fold change relative to H3.3-WT in XIII and b XVII ***p value < 0.001. c Gene tracks with ATAC-seq peaks from UCSC Genome Browser of select super-enhancer regions of interest. d COBL and OLIG2 were selected for validation using qPCR. Fold change expression in H3.3K27M DIPG were calculated relative to H3.3-WT. n = 4, *p value < 0.05, and error bars were calculated based on SEM