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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

Fig. 3

H3.3K27M and H3.3-WT DIPG have differentially accessible enhancer regions. a GREAT analysis of differentially open chromatin regions between parental (XIII and XVII) and CRISPR gene-edited isogenic wild-type lines (XIII-WT). b Gene tracks including our ATAC-seq peaks (parental=blue, wild-type=red), H3K27ac peaks from Nagaraja et al., 2017 GEO: GSE94259 [27] (black), and enhancer regions defined by GREAT analysis for genes of interest (green bar at the top)

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Epigenetics & Chromatin

ISSN: 1756-8935