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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers

Fig. 2

TF binding signatures at FOXA1-associated emCpGs versus de novo methylation-protected CpGs in breast cancer. A Beeswarm plot depicting TFBS sets enrichment (y-axis) specific to regions surrounding emCpGs associated with FOXA1. Each point corresponds to a TFBS data set in UniBind (one colour per TF, see legend). B Beeswarm plot depicting TFBS sets enrichment (y-axis) specific to regions surrounding non-correlated CpGs, which are close to FOXA1 TFBSs but whose DNA methylation levels do not correlate with FOXA1 expression in breast cancer samples. C Density distribution (y-axis) of GC contents (x-axis) at regions surrounding FOXA1 emCpGs (purple) and non-correlated CpGs (green). D Density distribution (y-axis) of mean methylation levels (x-axis) across breast cancer samples for FOXA1 emCpGs (purple) and non-correlated CpGs (green)

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Epigenetics & Chromatin

ISSN: 1756-8935