Fig. 5
From: Evolutionary adaptation of the Polycomb repressive complex 2
Simplified comparison of PRC2.1 and PRC2.2 chromatin binding in Drosophila and mammals. In Drosophila, PRC2 localizes to Polycomb response elements (PREs) and is recruited by Pho and Sfmbt proteins, as well as other transcription factors (TFs). Nonspecific DNA binding of Pcl, Jarid2 and Jing also contributes to PRC2 chromatin recruitment. In mammals, PRC2.1 is mainly located at unmethylated CpG islands (CGIs), recognized by the DNA binding winged-helix domain of the PCL proteins. Additional binding features of the associated factors may recruit distinct PRC2.1 subcomplexes to other DNA binding sites. PRC2.2 recruitment to chromatin depends on JARID2 recognition of H2Aub-modified nucleosomes, mediated by the PRC1 complex, as well as nonspecific DNA binding of AEBP2 and JARID2