Fig. 3
From: Evolutionary adaptation of the Polycomb repressive complex 2
Schematic overview of the evolution of the SKIDA1, SKIDA1-like, and EPOP proteins. A The C-terminal region (CTR) of the proteins binds to the PRC2 core [31] and is conserved among all proteins. In SKIDA1 and SKIDA1-like the N-terminal region contains a putative DNA binding SKI/SNO/DAC domain, which is replaced by a BC-box-containing region in EPOP. B Phylogenetic comparison of SKIDA1, SKIDA1-like and EPOP proteins from five representative organisms in fish (Astyanax mexicanus, Esox lucius, Fundulus heteroclitus, Danio rerio, Lepisosteus oculatus), amphibians (Xenopus laevis, Bufo bufo, Microcaecilia unicolor, Rhinatrema bivittatum, Geotrypetes seraphini), reptiles (Alligator mississippiensis, Anolis carolinensis, Chrysemys picta bellii, Protobothrops mucrosquamatus, Thamnophis sirtalis), birds (Coturnix japonica, Apteryx australis mantelli, Haliaeetus leucocephalus, Pseudopodoces humilis, Parus majo) and mammals (Homo sapiens, Balaenoptera musculus, Equus przewalskii, Mesocricetus auratus, Capra hircus), respectively, using ClustalOmega [91]. The tree was visualized using iTOL [92]