Fig. 1
From: Evolutionary adaptation of the Polycomb repressive complex 2
Overview of the main PRC2 members and their competition in Drosophila (A) and mammals (B), as well as their evolutionary occurrences (C). Mammalian complexes with one of the Polycomb-like proteins (PHF1, MTF2, or PHF19) are named PRC2.1, while complexes including AEBP2 and JARID2 are referred to as PRC2.2. Related complex members in Drosophila and mammals are indicated by similarly colored groups. Members of the catalytic core are illustrated in green, whereas Pcl and the respective PRC2.1 subcomplex members are indicated in blue. Mammalian PRC2.1 can have additional proteins such as EPOP, SKIDA1, and PALI1/2 (yellow), which compete against each other, allowing multiple PRC2.1 complex compositions (see also Fig. 6). Jing, Jarid2, and the respective mammalian PRC2.2 subcomplex members AEBP2 and JARID2 are colored red. The mammalian-specific protein EZHIP (purple) interacts with PRC2 in a subcomplex-independent manner