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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Making sense of the linear genome, gene function and TADs

Fig. 1

Features of autosomal TADs in ESCs and cortical neurons. A The number of TADs called using Arrowhead and TopDom in ESCs and cortical neurons. More TADs are called in ESCs than cortical neurons with both TAD callers. B Size of TADs called using Arrowhead and TopDom in ESCs and cortical neurons (plotted on a log10 scale). Both Arrowhead and TopDom call significantly smaller TADs in ESCs than cortical neurons (Wilcoxon test, p-value: p < 0.001 = ***, p < 0.01 = **, p < 0.05 = *, ES = effect size calculated using r for Wilcoxon). C The number of TADs per chromosome is strongly correlated with the size of the chromosome. D In both cell types and with both TAD callers most TADs have few genes. Overall, there is a low correlation between TAD size and gene number. Several TADs containing many genes were further investigated and found to contain multiple members of large gene families (annotated)

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