Fig. 7
From: Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Schematics for the molecular events of the nuclear deformation induced by TGFβ1 stimulation. TGFβ1 treatment phosphorylates and activates the SMAD complex, thereby increasing transcription and the protein level of histone H3.3. The subsequent nucleosome incorporation of H3.3 may facilitate a dynamic chromatin environment that allows for further recruitment of histone H1.4/H1.5 variants, and the interaction with H3K27me3 for nuclear deformation and NE rupture