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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells

Fig. 7

Chromatin landscape at the Lefty locus in mESCs and during induced differentiation. A IGV browser alignment of H3K56ac CUT&RUN enrichment and ATAC-seq patterns at the Lefty locus. Coherent broad domains of H3K56ac enrichment were identified by SEACR analysis and are denoted as blue bars. Differential enrichment and correlative accessibility change at known enhancers (shaded light green) and TSS (shaded gray). B Putative model of key transitions in chromatin accessibility, nucleosome stability and transcription factor binding* at enhancers*# and TSS sites within the Lefty locus in response to HDAC inhibitor treatment (adapted from *[65] and #[64]). C H3K56ac and OCT4 (POU5F1) ChIP-qPCR data following immunoprecipitation and amplification of regulatory sequences of the Lefty1 locus (P < 0.05). IgG was used as negative control

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