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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells

Fig. 3

Altered chromatin accessibility following VPA-induced differentiation. (A) ATAC-seq heatmaps of tag distributions across promoters in control and VPA-treated (2 mM, 48 h) samples. B Volcano Plot of differential ATAC-seq peaks. Loci with significant loss (red, n = 3923) and gain (green, n = 1614) of chromatin accessibility in VPA-treated cells are highlighted. C Comparative analysis of changes in the accessibility of peaks overlapping with different types of transposable elements (TEs) as a proportion of the total number of differential TE-overlapping peaks (%). D Top-most regulated loci with increased chromatin accessibility. E Top 10 over-represented GO Terms of biological processes (-log p-value). F Over-represented Kegg pathways identified in VPA-treated cells (-log p-value)

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Epigenetics & Chromatin

ISSN: 1756-8935