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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: One-pot universal NicE-seq: all enzymatic downstream processing of 4% formaldehyde crosslinked cells for chromatin accessibility genomics

Fig. 5

One-pot UniNicE-seq comparison with formaldehyde fixed ATAC-seq (ATAC-see) in GM12878 cells. A Genome-wide comparison of accessible chromatin between one-pot UniNicE-seq 25 and 500 cells with formaldehyde fixed ATAC-seq 50,000 cells (ATAC-see) using Pearson correlation. B Comparison of FRiP scores of one-pot UniNicE-seq 25 and 500 cells with fixed ATAC-seq 50,000 cells (ATAC-see). C Genome-wide metagene plot of TSS (top panel) and enhancer elements (bottom panel) with ± 2 Kb of flanking region of one-pot UniNicE-seq 25 cells, 500 cells and fixed ATAC-seq 50,000 cells. D Representative IGV screenshot of the normalized read density of the one-pot UniNicE-seq 25 cells, 500 cells and fixed ATAC-seq 50,000 cells

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