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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: The solid and liquid states of chromatin

Fig. 5

Nuclear bodies visualized by transmission electron microscopy. A K562 cell nucleus obtained by fixation with 4% paraformaldehyde and embedding in Epon 812 was imaged by electron spectroscopic imaging at 250 eV energy loss. This generates high contrast images of the biological specimen where contrast is related to the mass density. The image shows examples of condensed chromatin, the nucleolus, a Cajal body, and an interchromatin granule cluster (splicing factor compartment). The brightness was increased in the regions containing these structures to highlight their locations. The classification is based upon their morphologies in the transmission electron microscope. The scale bar represents 1 µm

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