Fig. 4

Differential enrichment of H3K9me3 at satellite elements during fetal development in mouse. a Two-dimensional PCA plot of mouse samples from diverse tissues across fetal development stages based on H3K9me3 enrichment at 28,937 autosomal satellite elements. Ellipses define 95% confidence intervals around group mean. Samples are colored by developmental stage (days after conception) as indicated by the legend. Days_0 denotes samples collected after birth. b Heatmap shows Z-score of FC values at 864 differentially enriched satellite elements on autosomal chromosomes. Stages are indicated by color above the heatmap. Tissues are shown per column and labeled in colored font by developmental stage (EFP—embryonic facial prominence). Satellite DNA instances are shown by row. Satellite families are color-coded on the left of the heatmap, as indicated in the legend. c distribution of FC per sample calculated for all annotated satellite DNA elements (red; N = 28,937) and elements with differentially enriched H3K9me3 (green; N = 864). Points denote median values and lines represent interquartile ranges